NFL Week 12 games lines: Lions, Cowboys, 49ers big Thanksgiving Day favorites

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Week 12 is a full slate with 16 games spread out over four days. It all starts Thursday with a Thanksgiving triple-header; the Green Bay Packers at the Detroit Lions, Washington Commanders at Dallas Cowboys and San Francisco 49ers at Seattle Seahawks. Friday, the Miami Dolphins visit the New York Jets, while Sunday’s slate will conclude with the Baltimore Ravens at the Los Angeles Chargers on Sunday night. To cap off the week, the Chicago Bears will visit the Minnesota Vikings for Monday Night Football on ABC and ESPN. We’ve got lines for every matchups, updated throughout the week.

Football Power Index (FPI) by ESPN Sports Analytics Group. Odds by ESPN BET.


Green Bay Packers @ Detroit Lions -7.5
Ford Field, Detroit
Thursday 12:30 p.m. ET


Money Line: Green Bay Packers (+300) ; Detroit Lions (-380)
Total: 46.5 (third highest of the week)
FPI favorite: Lions by 4.8 (64.1% to win outright)


Washington Commanders @ Dallas Cowboys -11
AT&T Stadium, Arlington, Texas
Thursday 4:30 p.m. ET


Money Line: Washington Commanders (+425) ; Dallas Cowboys (-550)
Total: 48.5 (Highest of the week)
FPI favorite: Cowboys by 13.9 (85.2% to win outright)


San Francisco 49ers -7 @ Seattle Seahawks
Lumen Field, Seattle
Thursday 8:20 p.m. ET


Money Line: San Francisco 49ers (-320) ; Seattle Seahawks (+260)
Total: 43.5 (ninth highest of the week)
FPI favorite: 49ers by 8.3 (73.3% to win outright)


Miami Dolphins -7.5 @ New York Jets
MetLife Stadium, East Rutherford, New Jersey
Friday 3 p.m. ET


Money Line: Miami Dolphins (-360) ; New York Jets (+290)
Total: 41.5 (12th highest of the week)
FPI favorite: Dolphins by 9.6 (76.5% to win outright)


New Orleans Saints @ Atlanta Falcons -1
Mercedes-Benz Stadium, Atlanta
Sunday 1 p.m. ET


Money Line: New Orleans Saints (-105) ; Atlanta Falcons (-115)
Total: 42.5 (10th highest of the week)
FPI favorite: Saints by 2.3 (56.9% to win outright)


Pittsburgh Steelers -1 @ Cincinnati Bengals
Paycor Stadium, Cincinnati
Sunday 1 p.m. ET


Money Line: Pittsburgh Steelers (-120) ; Cincinnati Bengals (+100)
Total: 34.5 (15th highest of the week)
FPI favorite: Steelers by 0.5 (51.4% to win outright)


Carolina Panthers @ Tennessee Titans -3.5
Nissan Stadium, Nashville, Tennessee
Sunday 1 p.m. ET


Money Line: Carolina Panthers (+165) ; Tennessee Titans (-195)
Total: 37.5 (13th highest of the week)
FPI favorite: Titans by 3.9 (61.6% to win outright)


Tampa Bay Buccaneers @ Indianapolis Colts -2
Lucas Oil Stadium, Indianapolis
Sunday 1 p.m. ET


Money Line: Tampa Bay Buccaneers (+105) ; Indianapolis Colts (-125)
Total: 42.5 (10th highest of the week)
FPI favorite: Colts by 1.6 (54.8% to win outright)


New England Patriots -3.5 @ New York Giants
MetLife Stadium, East Rutherford, New Jersey
Sunday 1 p.m. ET


Money Line: New England Patriots (-190) ; New York Giants (+160)
Total: 33.5 (16th highest of the week)
FPI favorite: Patriots by 8.1 (72.8% to win outright)


Jacksonville Jaguars -1 @ Houston Texans
NRG Stadium, Houston
Sunday 1 p.m. ET


Money Line: Jacksonville Jaguars (-115) ; Houston Texans (-105)
Total: 46.5 (third highest of the week)
FPI favorite: Jaguars by 2.5 (57.3% to win outright)


Cleveland Browns @ Denver Broncos -1.5
Empower Field at Mile High, Denver
Sunday 4:05 p.m. ET


Money Line: Cleveland Browns (+100) ; Denver Broncos (-120)
Total: 36.5 (14th highest of the week)
FPI favorite: Browns by 0.9 (52.6% to win outright)


Los Angeles Rams @ Arizona Cardinals (Pick)
State Farm Stadium, Glendale, Arizona
Sunday 4:05 p.m. ET


Money Line: Los Angeles Rams (-110) ; Arizona Cardinals (-110)
Total: 44.5 (sixth highest of the week)
FPI favorite: Rams by 5.5 (66.1% to win outright)


Kansas City Chiefs -9 @ Las Vegas Raiders
Allegiant Stadium, Las Vegas
Sunday 4:25 p.m. ET


Money Line: Kansas City Chiefs (-425) ; Las Vegas Raiders (+340)
Total: 44.5 (sixth highest of the week)
FPI favorite: Chiefs by 14.2 (85.6% to win outright)


Buffalo Bills @ Philadelphia Eagles -3.5
Lincoln Financial Field, Philadelphia
Sunday 4:25 p.m. ET


Money Line: Buffalo Bills (+150) ; Philadelphia Eagles (-175)
Total: 47.5 (2nd highest of the week)
FPI favorite: Bills by 2 (56% to win outright)


Baltimore Ravens -4 @ Los Angeles Chargers
SoFi Stadium, Inglewood, California
Sunday 8:20 p.m. ET


Money Line: Baltimore Ravens (-195) ; Los Angeles Chargers (+165)
Total: 46.5 (third highest of the week)
FPI favorite: Ravens by 2 (55.9% to win outright)


Chicago Bears @ Minnesota Vikings -3.5
U.S. Bank Stadium, Minneapolis
Monday 8:15 p.m. ET


Money Line: Chicago Bears (+145) ; Minnesota Vikings (-170)
Total: 44.5 (sixth highest of the week)
FPI favorite: Vikings by 4 (61.7% to win outright)

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